RNA Details
Disease Name
diabetic nephropathy
Tissue
kidney
RNA Symbol
mir-200b
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
RT-PCR;
Target
ZEB2;PTEN
Pathway
PI3K-AKT SIGNALING PATHWAY
PubMed ID
Title
The Alcohol Extract of Coreopsis tinctoria Nutt Ameliorates Diabetes and Diabetic Nephropathy in db/db Mice through miR-192/miR-200b and PTEN/AKT and ZEB2/ECM Pathways
Year
2019
Function
"Alcohol may protect the kidneys of diabetic nephropathies mice by decreasing miR-192 and miR-200b, which could further regulate their target gene expression and modulate the activity of the PTEN/PI3k/Akt pathway to reduce the degree of renal fibrosis."